Proteogenomics integrates genomics, transcriptomics, and proteomics to provide a more comprehensive picture of cellular activity. The Proteogenomics Consortium combines Seer’s Proteograph™ Product Suite and the SCIEX ZenoTOF 7600 system with Zeno SWATH DIA to provide a deep, rapid proteome assessment in biofluids at scale. This facilitates discoveries of variant proteins and novel biomarkers thus expanding our understanding of the proteome in an unbiased manner across a variety of cohorts and disease states.