For speed, scale and multiomic characterization choose Discovery
QUALITY IS A GIVEN
When you’re part of a team bringing cell therapies to market, access to high-quality human cellular material is critical. You have many options for quality leukopaks for the research phase of allogeneic cell therapy product development, but what happens when it’s time to transition to GMP compliant products for clinical use? Or you need to scale up?
Not only do we have a large, recallable donor pool that can ensure consistency and scale from research into clinical development and manufacturing, we have world-class genomics and flow cytometry labs just down the hall from our collection facilities, enabling fast, sophisticated multi-omic characterization.
Research, Development, & Manufacturing…
Discovery is the right choice for advancing your cell therapy programs.
ON DEMAND VIDEO
Streamline Cell Therapy Development with High Quality Cellular Materials, In-House Apheresis Capabilities & Multi-Omics Analytical Services
Learn how to leverage our integrated platform to advance your cell therapies - watch this video of Dr. Scott Burger’s presentation at the Allogeneic Cell Therapy Summit
Cell Therapy Products & Services
DISCOVERY FRESH LEUKOPAKS™ (RUO)
Scalable quantities of high-quality, well-characterized leukopaks. Same-day or next-day delivery available, depending on location.
DISCOVERY CRYO LEUKOPAKS™ (RUO)
High-quality, high-viability leukopaks with the convenience of cryopreservation.
DISCOVERY FRESH LEUKOPAKS™ (GMP)
Consistent and reliable production of GMP compliant leukopaks for clinical use at any scale. Combine with multi-omic analysis for deeper insights.
CRYOPRESERVED, IMMUNE CELL ISOLATIONS
Get study-ready immune cell isolates using our world-class on-site flow cytometry facility.
NEXT GENERATION SEQUENCING SERVICES
Discover genomic insights at scale through our HudsonAlpha Discovery lab’s sequencing technologies and optimized workflows.
See the complete range of custom cell services, including genomics, flow cytometry, cell culturing, and biospecimen processing.
Cell - Based Biomarkers
Leverage Discovery’s expert cell-based services to conduct targeted immunophenotyping, functional and other cell-based studies and analyses.
The ability to screen and process fresh human biospecimens (including fresh tissue) with customizable criteria and protocols allows our lab to deliver high-quality cell products, tailored for specific downstream applications..
- Standardized and customizable protocols available for cellular processing of human blood and tissue (tumor, diseased, and normal)
- Downstream cellular subset isolations available via magnetic bead separation and FACS based sorting
- Custom sample preparation such as spiked or contrived samples
Flow Cytometry and Cell Sorting
Multiparametric flow cytometry and cell sorting that can be performed in many sample types including: whole blood, primary cells, fresh or frozen PBMCs (diseased and/or normal), cell lines, and dissociated diseased and normal tissues and their cellular subsets. Panels include standardized and customizable panels for major cell subsets of the innate and adaptive immune system. Functional assays include evaluation of proliferation, apoptosis, cytotoxicity, and cytokine secretion.
- Phenotypic profiling
- Functional profiling
- FACS Based Cell Sorting
In Vitro Cell
Primary cell culture of cells derived from human blood and tissue to evaluate growth characteristics, phenotypic changes, and drug responses. Including:
- T cell expansion
- Macrophage and dendritic cell differentiation from monocytes
- Custom drug sensitivity assays - IC50 studies
Single-cell sequencing library prep on the 10x Chromium platform, including specialized sample preparation, multiple QC checks throughout library construction, and pipeline data analysis.
- Single Cell Gene Expression (scRNASeq)
- Single Cell Immune Profiling (TCRSeq, BCRSeq)
- Feature Barcoding (CITESeq)
Frequently Asked Questions
How are your donors characterized?
- Smoking status
- Blood type
HLA-typing to 6-digit resolution with NGS
Virus testing every 90 days
- Hepatitis B Core Antibody (Anti-HBc EIA)
- Hepatitis C Virus Antibody (Anti-HCV EIA)
- Human Immunodeficiency Virus Antibody (HIV 1/2 plus O)
- Additional tests can be performed— please inquire.
Other genomic or flow cytometry characterizations available as add-on services
Your samples are all from healthy, normal donors—how do you define “normal"?
For a donor to qualify as normal, they cannot be currently diagnosed or have a history of cancer, autoimmune disease, or any major comorbidity (i.e. diabetes, high blood pressure, etc.). Contact us to learn more.
Can I follow the same donor from RUO to GMP?
Has COVID-19 affected your collection, processing, and/or analytical facilities?
Where are you located?
To propel your projects with The Power of Discovery.™
Contact Us Today
Let us know about your project!