Human Tissue Sample Blog

The Benefits of Using Patient Derived CRC Primary Cultures for Research

Posted by Luke Doiron on Sep 29, 2015 9:00:00 AM

    

 

It can cost up to $4 billion and take, on average, 12 years to bring a new drug to market. One of the biggest challenges for R&D is improving the early clinical discovery steps, so that better potential candidate molecules make it into human clinical trials. It’s increasingly recognized that one of the main reasons for the large number of drug failures is the use of models that are not predictive or are irrelevant to understanding critical disease mechanisms.

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The Many Metastatic CRC Models to Use for Research

Posted by Luke Doiron on Sep 15, 2015 12:08:00 PM

    

Colorectal cancer (CRC) is the third most common cancer worldwide and in the U.S. Because it is increasing in incidence and is often diagnosed late, there is great urgency for good models to study CRC and to identify diagnostic tools and effective drug therapies. One of the most important tools is the cellular or animal model, both of which help in pre-clinical investigation of novel compounds, toxicity, sensitivity and resistance research. Over the past years, a wide range of models have been developed and tested for reliable predictive value in human clinical studies.

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4 Indications for Xenograft Tissue Samples

Posted by Luke Doiron on Jul 9, 2013 7:55:00 AM

    

Xenografts are commonly used for disease research when a model is needed that closely resembles a growing tumor. Xenografts have been an important part of pre-clinical drug research for many years. The term describes a group of cells that are implanted into a different species, typically immunosuppressed mice. This sometimes provides a more accurate and reliable model than using in-vitro grown cells. Here are examples of recent pre-clinical studies using xenograft tissue samples:

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7 Applications for Whole Processed Tissue

Posted by Luke Doiron on Apr 2, 2013 8:00:00 AM

    

 


High-quality human tissue specimens are invaluable for researchers seeking to unlock the mysteries of the human body, discover the cause of hard-to-cure diseases such as cancer and ultimately, bring therapeutic solutions to waiting patients. Since researchers can’t do pre-clinical early-stage testing on human volunteers, they rely on modern tissue banks to provide ethically-collected, highly-annotated tissue specimens.

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5 Cutting Edge Applications for Bone Marrow Samples

Posted by Luke Doiron on Jan 15, 2013 9:00:00 AM

    

Bone marrow is critically important for identifying and understanding the reason for a wide array of human blood and autoimmune diseases, as well as a source for stem cells that are increasingly important for a whole range of scientific projects. Researchers look to human tissue providers for bone marrow samples from both normal and diseased patients. These samples can be prospectively obtained fresh samples or come from purified bone marrow mononuclear cells.  

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