Human Tissue Sample Blog

Why Do Researchers Need Healthy Samples?

Posted by Quinton Stevens on Feb 14, 2017 5:02:00 AM

    

Introduction

In medical studies, doctors and pharmaceutical professionals often need tissue samples to test drugs or other stimuli out and in doing so, learn more about the human body. It comes as no surprise, then, that tissue with a certain disease or other maladies would be of great value to researchers.

This tissue is often subject to advanced testing to see if new breakthrough drugs will be better than their predecessors without risking any living person. It also means there is a lot more room for trial and error, as no person’s quality of life is in direct jeopardy.

One lesser known side of this wonderful process is the need for what is called a “control group.” In every experiment, scientists need a group that is unaltered by experimentation so that they can tell when something has changed. This control group in the case of human samples is tissue (often blood) from perfectly healthy individuals.

Read More

Allergies: Whats Happening Inside the Body

Posted by Quinton Stevens on Feb 27, 2016 12:45:00 PM

    

Read More

3 Things You Need to Know About Pluripotent Stem Cells

Posted by Quinton Stevens on Feb 21, 2016 12:15:00 PM

    

One of the unfortunate aspects of life is disease. Though disease comes in many shapes, sizes, and varieties, by some means it always aims to cause harm. Some of the more severe kinds can leave permanent marks upon their victims; such as damaged organs or tissue loss. Living with such impairments has been largely untreatable for the majority of human history.

Organ transplantation has traditionally been an ideal treatment for replacing failed organs, but what then did people who couldn’t get transplants for critical organs do? Or what about people with damage to body systems where transplant isn’t possible? Sadly, there isn’t a happy answer to those questions. In most cases, people’s quality of life remains lowered if they survived severe organ damage.

Read More

5 Research Applications for Normal Tissue Samples

Posted by Luke Doiron on Jan 28, 2016 7:00:00 AM

    

Scientists aiming to find the causes and cures for some of our most intractable diseases, such as cancer and immune disorders, need access to a complete range of high-quality, well-annotated specimens, from both disease and normal tissue samples. Why, you might ask, would a researcher need specimens from healthy individuals? There are in fact, lots of reasons why normal tissue specimens are invaluable research resources. In general, researchers studying oncology, immunology and hematology indications routinely need access to benign nodes and normal adjacent tissue from the same disease to use as controls. Here are five research applications employing normal tissue samples:

Read More

Beyond the Basics: 14 Components of Normal Bone Marrow You Might Have Missed

Posted by Luke Doiron on Jan 20, 2015 6:00:00 AM

    

 

The normal bone marrow is the sole site of effective hematopoiesis in humans, and occurs in the soft, spongy, gelatinous tissue found in the hollow spaces in the interior of bones.The average weight of this tissue is about 4% of the total body weight, or 2.6 kg in an adult weighing 65 kg. It consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma.

Read More

6 Challenges to Using Adult Stem Cells in Hematology Research

Posted by Luke Doiron on Jan 13, 2015 6:00:00 AM

    

Adult stem cells can be generated from a variety of organs, ranging from the brain’s neural cells, to the skin. The most accessible stem cells and progenitor cells however, are found in bone marrow, which is rich with these cells. This type of “therapy” has potential; benefit for a variety of diseases, including many neurological diseases, such as strokes, spinal-cord injury, Alzheimer’s disease, Parkinson’s disease, and Lou Gehrig’s disease.

Read More

Four Downstream Applications for Isolated Peripheral Blood Mononuclear Cells

Posted by Rachel Lane on Nov 25, 2014 6:00:00 AM

    

 

Peripheral blood mononuclear cells (PBMCs), which mainly include lymphocytes (i.e., T cells, B cells, and natural killer [NK] cells) and monocytes, are a valuable research tool. This cell population is usually isolated from whole blood via simple density gradient centrifugation, and fresh or cryopreserved PBMCs can be used for studies. PBMCs are a versatile cell population with applications in multiple research fields, including those listed below. 

Read More

Maintaining Quality in Peripheral Blood Products for Diabetes Research

Posted by Luke Doiron on Aug 27, 2013 12:00:00 PM

    

Do you view the human biospecimens used for drug discovery as critical organizational assets? Consider this: As pre-clinical drug discovery moves deeper into the molecular level, and as the business of personalized medicine advances, your company must pay careful attention to every biospecimen it utilizes. Those specimens need to be properly handled and deeply annotated to ensure that derived research results are reliable. Organizations that strategically manage their specimens can often lower R&D costs, bring new therapies to market more quickly and reduce liability risks due to unforeseen side effects.

Read More

Subscribe to the Conversant Bio blog

New Call-to-action