Target Expression

Unique integrated biospecimen and expert multi-omic services
– flow cytometry, ELISA, sequencing and IHC –
enable a thorough understanding of target expression.
Study Design and Cohort Creation
  • Define specific tissue characteristics desired
  • Develop a strategy for a cohort of low prevalence biomarkers
  • Select FFPE specimens matching study criteria from our biobank or initiate a prospective collection using our global clinical site network of Discovery Partners
  • Identify proper controls
  • Create custom FFPE positive and negative controls verified by flow cytometry
  • Comprehensive multi-omic orthogonal validation services – flow cytometry, ELISA, IHC and sequencing.
Understand Target Expression
  • Conduct large scale sensitivity screening of cancer patient populations to understand expression patterns within and among tumor indications
  • Demonstrate precision and reproducibility using serial sections from samples with various levels of known target expression (from sensitivity screen): Learn More »
  • Analyze specificity in cell lines, xenografts, and normal human tissues
  • Develop a robust scoring scheme to properly and consistently capture level of target expression
  • Analyze expression rate for cut-off determination in various disease indications
Precision & Reproducibility See an Example

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