Epigenomic Sequencing Services

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Flexible options enable your epigenomic studies

Identifying sites of epigenetic modification can shed light on developmental pathways, pathogenic processes, transcriptional regulation, and serve as biomarkers for disease.

HudsonAlpha Discovery provides a range of epigenetic sequencing services to advance all phases of research studies, including basic, discovery, translational, pre-clinical, and clinical research.

Highlights

Advance insight into the regulation of gene expression with epigenetic sequencing
Flexible and customizable end-to-end services
Illumina’s Infinium MethylationEPIC BeadChip 850K Array technology

Single-cell ATAC-seq with 10x Genomics technology
Next generation sequencing (NGS) of bisulfite-treated libraries

Applications

Development

Biomarker discovery

Disease research

All research phases and activities

Basic discovery, Translational and pre-clinical, Clinical

Highlights of our epigenetic sequencing services

Whether you need end-to-end support or a subset of what we can provide, we’ll help you customize a service project to best meet your study objectives.

Here are a few examples of what we offer:
Nucleic acid extraction and library preparation
  • Optimized extraction protocols for nearly any sample type
  • Optimized protocols for working with ultra-low amounts of nucleic acid
  • Dual concurrent RNA-DNA extraction from challenging sample types such as FFPE tissue— read the white paper »
Assay Technologies
  • Whole Genome Bisulfite Sequencing
  • Illumina’s Infinium MethylationEPIC BeadChip 850K Array technology
  • Single cell chromatin accessibility studies with ATAC-seq (10x Genomics)
  • Oxford Nanopore DNA methylation analysis
  • NGS sequencing of already-prepared libraries including bisulfite-treated DNA
Bioinformatics analysis and data storage
  • Tier 1: Raw BCL and FASTQ file output
  • Tier 2: Standard application-specific and quality report outputs (BCL, FASTQ, aligned BAM files and sequencing QC reports
  • Tier 3: Standard output plus variant calling (VCF, g-VCF) and genomic interpretation reports
  • Additional custom reporting options including Ingenuity Variant Analysis (Qiagen) consolidated variant reports as well as options for genomic variant annotation
  • Flexible data delivery and storage options
  • 90 days storage included with service