ONE OF THE LARGEST GENOMIC SERVICES LABS WITH INDUSTRIAL-SCALE CAPABILITIES
Advance With Confidence
NovaSeq 6000
Quantity - 9
Sequel IIe
Quantity - 20
NextSeq 550
MiSeq
ISeq 100
PromethION
Chromium Controller
Chromium Connect Automated Controller
NCounter Flex
A WORLD-CLASS GENOMIC SERVICES LAB WITH INDUSTRIAL-SCALE CAPABILITIES
Genomic Biomarkers
Whole Genome Sequencing
Scalable whole genome sequencing services with the coverage and quality to meet your project needs.
- Illumina, PacBio, and
Oxford Nanopore platforms - 30x, 60x, 90x, custom
coverages options - Matched DNA - and RNA -
Seq from the same tissue
Targeted & Exome
Sequencing
Multiple options for coverage, targeted sequencing panels, and capture platforms enable basic, translational, and clinical studies.
- IDT, Twist, Agilent capture platforms
- 50x, 100x, 300x, and custom coverage
- Illumina TruSight panels
RNA-SEQ
Proprietary isolation protocols deliver high quality RNA even from difficult samples.
- Multiple RNA types, including
mRNA, long non-coding RNA,
miRNA, regulatory RNAs,
exosomal RNA - Robust RNA isolation from
FFPE tissue - Multiple RNA amplification
and library construction
methods from both low and
high quality RNA
Single Cell Sequencing
Scalable whole genome sequencing services with the coverage and quality to meet your project needs.
- 10x, Genomics technologies
- RNA-Seq, TCR-Seq, BCR-
Seq, CITE-Seq, and ATAC-Seq - 10x Genomics Cell Ranger
Analysis - Qualitative and
quantitative analyses
Epigenomics
Multiple options for coverage, targeted sequencing panels, and capture platforms enable basic, translational, and clinical studies.
- Illumina’s Infinium
MethylationEPIC BeadChip
(850K sites) technology - ATAC-Seq with 10x
Genomics technology - 10x Genomics Cell Ranger
Next generation sequencing
(NGS) of bisulfite-treated
libraries
Metagenomics
Proprietary isolation protocols deliver high quality RNA even from difficult samples.
- Nucleic acid extraction from environmental and clinical samples
- Whole genome shotgun
metagenomics - Metatranscriptomic
sequencing - 16S rRNA sequencing
The HudsonAlpha Difference
High-Throughput Capacity
Our 10 Illumina NovaSeq 6000 instruments can sequence ~70,000 whole genomes per year, enabling projects at any scale.
Largest PacBio Certified Service Provider
We can leverage both PacBio and Oxford Nanopore long-read platforms for better insights into genome structure including large structural variants, long repeats, and more.
Optimized Workflows
We consistently generate reproducible, high-quality data from even the most challenging samples, such as FFPE and low sample input amounts.
WORKFLOWS OPTIMIZED TO REDUCE TECHNICAL BIAS:
High-Quality Biospecimens
As part of Discovery Life Sciences, we can source a range of healthy and disease-state biospecimen types for your study, including matched FFPE tissue and plasma.
Bioinformatics Services
We have multiple options for data analysis and interpretation including short- and long-term data storage.
Flexible, Fully Cusomizable End-to-End Service
We can create customized solutions that overcome a wide range of challenges.
With hundreds of thousands of research and clinical samples successfully analyzed using whole genome, whole exome, whole transcriptome, and other more targeted genomic approaches, HudsonAlpha Discovery is the right partner to bring genomic insights to your project.
Propel Your Research
When you choose HudsonAlpha Discovery you get the latest genomic innovations delivered at speed and scale—proprietary workflows, advanced sequencing platforms, and the Discovery Life Sciences commitment to service.
QUALITY IS A GIVEN
Comprehensive Sequencing Analysis
Our genomics portal simplifies your access to comprehensive bioinformatics and includes convenient data storage solutions.
- Tier 1: Raw BCL and FASTQ file output
- Tier 2: Standard application-specific and quality report outputs (BCL, FASTQ, aligned BAM files and sequencing QC reports
- Tier 3: Standard output plus variant calling (VCF, g-VCF) and genomic interpretation reports
- RPKM, FPKM, Differential Expression Analysis, Fusion Detection, Splice Site Isoform Detection, Ingenuity Pathway Analysis
- Additional custom reporting options including Ingenuity Variant Analysis (Qiagen) consolidated variant reports as well as options for genomic variant annotation
- Flexible data delivery and storage options
- 90 days storage included with service pricing
- Long term storage available
Technical Bias
At HudsonAlpha Discovery, our commitment to quality and reproducibility can be seen in the steps we take to reduce technical bias (Figure 1). These steps include:
- Automation to ensure consistency
- Multiple points to assess quality
- iSeq sequencers to balance library pools before sequencing
- Distributed sequencing of balanced library pools across flow cells and sequencers to normalize variability
Figure 1. An example of a sequencing workflow that limits technical bias.
IN A LONGITUDINAL STUDY THAT TESTED THOUSANDS OF SAMPLES, WE DEMONSTRATED A PLATE TO PLATE VARIABILITY OF <1%
To propel your projects with The Power of Discovery.™
Contact Us Today
Let us know about your project!
