Discovery Genomics

One of the world’s largest commercial genome centers brings together advanced technologies and leading in-house experts to plan data strategies that deliver high-quality results rapidly for projects of any scale.

 

Limited-Time Promotion 

WGS, WES, and RNA-Seq on NovaSeq® X Plus

For a limited time, fill out the form below to get our special offers on WGS, WES, and RNA-Seq performed on NovaSeq® X Plus systems. These offers end on July 4th, 2023. Click here to see our X Plus WGS, WES, and RNA-Seq performance data.

Illumina NovaSeq® X Plus systems provide higher throughput, lower cost per read, and faster turnaround time.  Discovery Genomics is on track to have the world's largest Illumina® NovaSeq® X Plus commercial fleet.  See Press Release.

 

ONE OF THE LARGEST GENOMIC SERVICES LABS WITH INDUSTRIAL-SCALE CAPABILITIES

Advance With Confidence

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NovaSeq X Plus

Quantity - 2 (will expand to 5 by the end of 2023)

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NovaSeq 6000

Quantity - 9

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NextSeq 550

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MiSeq

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ISeq 100

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Sequel IIe

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PromethION

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Chromium Controller

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Chromium Connect Automated Controller

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NCounter Flex

A WORLD-CLASS GENOMIC SERVICES LAB WITH INDUSTRIAL-SCALE CAPABILITIES

Genomic Services

Whole Genome Sequencing

Scalable whole genome sequencing services with the coverage and quality to meet your project needs.

  • Illumina, PacBio, and
    Oxford Nanopore platforms
  • 30x, 60x, 90x, custom
    coverages options
  • Matched DNA - and RNA -
    Seq from the same tissue

Targeted & Exome
Sequencing

Multiple options for coverage, targeted sequencing panels, and capture platforms enable basic, translational, and clinical studies.

  • IDT, Twist, Agilent capture platforms
  • 50x, 100x, 300x, and custom coverage
  • Illumina TruSight panels

RNA-SEQ

Proprietary isolation protocols deliver high quality RNA even from difficult samples.

  • Multiple RNA types, including
    mRNA, long non-coding RNA, 
    miRNA, regulatory RNAs,
    exosomal RNA
  • Robust RNA isolation from
    FFPE tissue
  • Multiple RNA amplification
    and library construction
    methods from both low and
    high quality RNA

Single Cell Sequencing

Scalable whole genome sequencing services with the coverage and quality to meet your project needs.

  • 10x, Genomics technologies
  • RNA-Seq, TCR-Seq, BCR-
    Seq, CITE-Seq, and ATAC-Seq
  • 10x Genomics Cell Ranger
    Analysis
  • Qualitative and
    quantitative analyses

Epigenomics

Multiple options for coverage, targeted sequencing panels, and capture platforms enable basic, translational, and clinical studies.

  • Illumina’s Infinium
    MethylationEPIC BeadChip
    (850K sites) technology
  • ATAC-Seq with 10x
    Genomics technology
  • 10x Genomics Cell Ranger
    Next generation sequencing
    (NGS) of bisulfite-treated
    libraries

The Discovery Genomics Difference

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High-Throughput Capacity

Our 10 Illumina NovaSeq 6000 instruments can sequence ~70,000 whole genomes per year, enabling projects at any scale.

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Largest PacBio Certified Service Provider

We can leverage both PacBio and Oxford Nanopore long-read platforms for better insights into genome structure including large structural variants, long repeats, and more.

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Optimized Workflows

We consistently generate reproducible, high-quality data from even the most challenging samples, such as FFPE and low sample input amounts.

WORKFLOWS OPTIMIZED TO REDUCE TECHNICAL BIAS:

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High-Quality Biospecimens

As part of Discovery Life Sciences, we can source a range of healthy and disease-state biospecimen types for your study, including matched FFPE tissue and plasma.

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Bioinformatics Services

We have multiple options for data analysis and interpretation including short- and long-term data storage.

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Flexible, Fully Cusomizable End-to-End Service

We can create customized solutions that overcome a wide range of challenges.

Discovery Genomics

With hundreds of thousands of research and clinical samples successfully analyzed using whole genome, whole exome, whole transcriptome, and other more targeted genomic approaches, Discovery Genomics is the right partner to bring genomic insights to your project.

Propel Your Research

When you choose Discovery Genomics you get the latest genomic innovations delivered at speed and scale—proprietary workflows, advanced sequencing platforms, and the Discovery Life Sciences commitment to service.

QUALITY IS A GIVEN

Comprehensive Sequencing Analysis

Our genomics portal simplifies your access to comprehensive bioinformatics and includes convenient data storage solutions.

  • Tier 1: Raw BCL and FASTQ file output
  • Tier 2: Standard application-specific and quality report outputs (BCL, FASTQ, aligned BAM files and sequencing QC reports
  • Tier 3: Standard output plus variant calling (VCF, g-VCF) and genomic interpretation reports
  • RPKM, FPKM, Differential Expression Analysis, Fusion Detection, Splice Site Isoform Detection, Ingenuity Pathway Analysis
  • Additional custom reporting options including Ingenuity Variant Analysis (Qiagen) consolidated variant reports as well as options for genomic variant annotation
  • Flexible data delivery and storage options
  • 90 days storage included with service pricing
  • Long term storage available
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Technical Bias

At HudsonAlpha Discovery, our commitment to quality and reproducibility can be seen in the steps we take to reduce technical bias (Figure 1). These steps include:

  • Automation to ensure consistency
  • Multiple points to assess quality
  • iSeq sequencers to balance library pools before sequencing
  • Distributed sequencing of balanced library pools across flow cells and sequencers to normalize variability
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Figure 1. An example of a sequencing workflow that limits technical bias.

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IN A LONGITUDINAL STUDY THAT TESTED THOUSANDS OF SAMPLES, WE DEMONSTRATED A PLATE TO PLATE VARIABILITY OF <1%

To propel your projects with The Power of Discovery.™

Contact Us Today

Let us know about your project!

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