The Discovery Difference

The unique integration of our extensive biospecimen inventory, expert biospecimen processing capabilities, and flow cytometry services deliver a fast, cost-effective way to help you understand the phenotypic and functional biomarkers relevant in your studies. 

Our flow cytometry service projects begin with initial consultation to evaluate the cell populations, surface receptors, and intracellular markers required for the study.  Flow cytometry panels are then constructed and titrated to evaluate optimal antibody clones, fluorophores, and concentrations for the markers of interest.  Following full panel evaluation, panels are qualified on multiple unique physiologically samples to ensure optimal performance.  Functional assays, including cytotoxicity, apoptosis, proliferation, and cytokine secretion, are also available.

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Fresh or Frozen Biospecimens

  • Fresh or frozen
  • Cell isolations
  • Blood, tumor or tissue
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Expert Sample Processing    

  • Cell isolations
    - Magnetic of FACS
    - Custom sample preparation
    - Contrived or spiked samples
    - Cell suspensions via mechanical & enzymatic digestions
  • In Vitro cell culture services
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Analytical Services

Immunophenotypic Profiling

Our cell biology and immunology experts provide multiparametric flow cytometry standard panel services and custom panel development services with gating strategies to ensure you understand immunophenotypic biomarkers and cellular subsets. 

Standard Panels

  • PBMC TBNK
  • AML/MM PBMC/BMMC Blast
  • DTC Cellular Composition & Receptor Expression

Cell Population Enumeration

  • T Regulatory Cells, Dendritic Cells, MDSCs

Cell Functional State

  • T Cell Activation/Exhaustion Markers

Biomarker / Target Expression

  • Co-Inhibitory/Co-Stimulatory Molecules
  • PD1/PDL1 Expression

WATCH THE WEBINAR

Deep Multi-Omic Phenotyping Of Biospecimens For Immuno-Oncology Applications 

Functional Profiling

Our functional assays include evaluation of proliferation, apoptosis, cytotoxicity, and cytokine secretion with incorporation of optimal gating strategies.

Cytotoxicity Assays

  • E:T Ratio Evaluation
    - Gene Expression
    - microRNA
    - SNP Genotyping
  • Apoptosis Detection
    - Annexin V, 
       Cleaved Caspase 3/7 

Cell Proliferation

  • CFSE Dilution Assays

Cytokine Secretion

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Custom functional profiling projects are routinely performed. Contact us to tell us more about your project and experimental goals.

To propel your projects with The Power of Discovery.™

Contact Us Today

Let us know about your project!

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