Biomarker Specialists

Discovery’s expert multi-omic biomarker testing services are optimized for speed and large scale capacity. Our global biomarker service laboratories routinely manage hundreds of global studies and expertly test thousands of biospecimens simultaneously using NGS, IHC, flow cytometry and other technologies.

Genomic Biomarkers

A world-class genomic services lab with industrial-scale capabilities

HudsonAlpha Discovery brings together advanced technologies, workflows optimized for quality and reproducibility, and an innovative, service-oriented scientific team to deliver reliable scientific insight delivered rapidly and at scale.

Whole Genome Sequencing

Scalable whole genome sequencing services with the coverage and quality to meet your project needs.

  • Illumina, PacBio, and Oxford Nanopore platforms
  • 30x, 60x, 90x, custom coverage options
  • Matched DNA- and RNA-Seq from the same tissue
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Targeted & Exome Sequencing

Multiple options for coverage, targeted sequencing panels, and capture platforms enable basic, translational, and clinical studies.

  • IDT, Twist, Agilent capture platforms
  • 50x, 100x, 300x, and custom coverage
  • Illumina TruSight panels
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RNA-Seq

Proprietary isolation protocols deliver high quality RNA even from difficult samples.

  • Multiple RNA types, including mRNA, long non-coding RNA, miRNA, regulatory RNAs,exosomal RNA
  • Robust RNA isolation from FFPE tissue
  • Multiple RNA amplification and library construction methods from both low and high quality RNA
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Single Cell Sequencing

Improve the resolution of your genomic data with single cell sequencing

  • 10x Genomics technologies
  • RNA-Seq, TCR-Seq, BCR-Seq, CITE-Seq, and ATAC-Seq
  • 10x Genomics Cell Ranger Analysis
  • Qualitative and quantitative analyses
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Epigenomics

Advance insight into epigenetic regulation of gene expression

  • Illumina’s Infinium MethylationEPIC BeadChip (850K sites) technology
  • ATAC-Seq with 10x Genomics technology
  • Next generation sequencing (NGS) of bisulfite-treated libraries
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Metagenomics

Explore the microbiome with a range of metagenomic sequencing services.

  • Nucleic acid extraction from environmental and clinical samples
  • Whole genome shotgun metagenomics
  • Metatranscriptomic sequencing
  • 16S rRNA sequencing
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Tissue Biomarkers

Power your precision biomarker programs with pathology guided tissue biomarker services.

Make strategic decisions with confidence. Our experts help you identify and understand biomarkers within your target populations at every stage of research and clinical development – from assay development and validation to clinical trial support.

High quality IHC services fit for any stage of research and development

Preclinical and Translational Studies

We apply expert knowledge of fundamental biological processes to understand targets in preclinical models and accelerate transition to the next stage of development

Assay Development

Our experts start with the end in mind to tailor assays for the right targets in the right patients on the right platforms

Assay Validation

Expert determination and optimization of assay performance

Target Expression

Unique integrated biospecimen and expert multi-omic services - flow cytometry, ELISA, sequencing and IHC - enable a thorough understanding of target expression.

Clinical Trial Services

Get high quality results at speed and scale to accelerate global clinical trials using a single chain of custody that adheres to all appropriate regulations and quality standards

Companion Diagnostics

Leverage the expertise behind one of the most successful companion diagnostic on the market to advance your companion diagnostic programs

Pathology Biomarker Training Services

Accelerate adoption postmarket with expert training for pathologists and technicians

Cell-Based Biomarkers

Leverage Discovery’s expert cell-based services to conduct targeted immunophenotyping, functional and other cell-based studies and analyses.

Custom Biospecimen Processing

The ability to screen and process fresh human biospecimens (including fresh tissue) with customizable criteria and protocols allows our lab to deliver high-quality cell products, tailored for specific downstream applications.

  • Standardized and customizable protocols available for cellular processing of human blood and tissue (tumor, diseased, and normal)
  • Downstream cellular subset isolations available via magnetic bead separation and FACS based sorting
  • Custom sample preparation such as spiked or contrived samples

Flow Cytometry and Cell Sorting

Multiparametric flow cytometry and cell sorting that can be performed in many sample types including: whole blood, primary cells, fresh or frozen PBMCs (diseased and/or normal), cell lines, and dissociated diseased and normal tissues and their cellular subsets. Panels include standardized and customizable panels for major cell subsets of the innate and adaptive immune system. Functional assays include evaluation of proliferation, apoptosis, cytotoxicity, and cytokine secretion.

  • Phenotypic profiling
  • Functional profiling
  • FACS Based Cell Sorting

In vitro Cell Culture

Primary cell culture of cells derived from human blood and tissue to evaluate growth characteristics, phenotypic changes, and drug responses. Including:

  • T cell expansion
  • Macrophage and dendritic cell differentiation from monocytes
  • Custom drug sensitivity assays  - IC50 studies

10x Library Construction

Single-cell sequencing library prep on the 10x Chromium platform, including specialized sample preparation, multiple QC checks throughout library construction, and pipeline data analysis.

  • Single Cell Gene Expression (scRNASeq)
  • Single Cell Immune Profiling (TCRSeq, BCRSeq)
  • Feature Barcoding (CITESeq)

Need biospecimens to build your study cohorts?

Discovery is a global market leader in biospecimen analysis, procurement, and distribution for pharmaceutical, biotechnology, and diagnostics industries.

Discovery offers a full spectrum of biospecimen solutions for diseased patients and healthy donors. From small and simple projects to complex prospective studies, Discovery has the expertise, inventory and global clinical networks to meet your biospecimen needs.

View Biospecimen Inventory

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to propel your projects with The Power of Discovery.